PYRAZOLONE

Toxicology

Pyrasulfotole belongs to the pyrazolone family of compounds, and is a post-emergent herbicide.

 

Clinical management

A specific treatment protocol of pyrazolone has not yet been prepared. The following represents the general management of of individuals exposed to
potentially toxic chemicals.

DILUTION –
Immediately dilute the ingested toxicant with milk or water particularly following caustic or irritant chemical ingestion;no more than 240 mL in adults and 120 mL in children is recommended to minimize the risk of vomiting

GASTRIC LAVAGE
If significant esophageal or gastrointestinal tract corrosion may occur following ingestion, the possible benefit of early removal of some ingested
material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation.

Consider gastric lavage  after ingestion of a potentially life-threatening amount of poison that presents generally within 1 hour post ingestion. Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first.
ACTIVATED CHARCOAL
Activated charcoal generally binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. The dosage is 1g/kg bwt up to 100g in adults given orally as a slurry (240 mL water/30 g charcoal)

Observe patients with significant  ingestion  for the development of esophageal or gastrointestinal tract burns. If features  of
esophageal  burns are present, consider endoscopy to determine the extent of injury.

Noteworthy,however, is that respiratory tract irritation, if severe, can progress to pulmonary edema which may be delayed in onset up to 24 to 72 hours after exposure in some cases.

If bronchospasm and airway symptoms occur, consider treatment with beta-2 agonists such as salbutamol.

 

Reference

 

Toxnet, Toxicology Data Network. Pyrasulfotole. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+7879. Complete Update on 2012-02-14. Accessed 22/07/2019.

 

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