PYRIMIDINYL CARBOXY HERBICIDE

Toxicology

Pyrimidinylthiobenzoates

This family includes bispyribac-sodium, pyrithiobac-sodium,pyriminobac-methyl

Adjuvants such as non-ionic surfactants and petroleum based oils may be added to improve herbicidal efficacy

The mode of action has been considered as inhibition of acetolactate synthase (ALS-ase) in the biosynthetic pathway of three branched-chain amino acids .

Clinical Management

Because this class is of low toxicity the possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Consider gastric lavage after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placing the patient in the head down left lateral decubitus position or by endotracheal intubation. 

Administer activated charcoal after ingestion of a potentially life-threatening amount as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.

Check and correct fluid and electrolyte imbalances.

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